The Biomedical Neuroscience Institute (www.bni.cl) and the Geroscience Center for Brain Health and Metabolism (www.gerochile.cl) are seeking for highly-qualified and motivated applicants for a full time postdoctoral position at the laboratory of Proteostasis Control and Biomedicine of the University of Chile
Post-Doc Positions: Two positions available funded for a 2 to 3 year period.
Starting date: April 2019 or upon agreement.
Project: The project is part of a larger initiative involving collaboration with different labs in the US, Europe and Chile. This laboratory focuses on understanding the molecular basis of proteostasis control and its relationship to pathological conditions affecting the nervous system. The project aims to the study cellular strategies involved in adaptation to chronic endoplasmic reticulum (ER) stress. The ER has important cellular functions, highlighting its role as sophisticated machinery for protein folding and secretion. ER stress engages an integrated signaling pathway known as the “Unfolded Protein Response” (UPR), which aims to restore homeostasis. Nevertheless, the mechanisms that control the transition from an adaptive state to cell death processes remain unknown and is a central subject of our research. We are currently developing a systematic approach to underscore the effects of targeting the UPR in several brain diseases using preclinical models. He/she investigates signal transduction pathways regulating stress pathways (UPR, autophagy and apoptosis). Furthermore, he/she supports the Chair in teaching and student supervision.