Journal Protein Science highlights on its April cover publication of members of SBBMCH

Journal Protein Science highlights on its April cover publication of members of SBBMCH

La revista Protein Science destaca en su portada del número de abril de 2021 una publicación de miembros de la Sociedad de Bioquímica y Biología Molecular de Chile. Se trata de “Crystal structure and molecular dynamics simulations of a promiscuous ancestor reveal residues and an epistatic interaction involved in substrate binding and catalysis in the ATP‐dependent vitamin kinase family members”
The first author of this publication is Felipe González-Orders, phD student in Sciences mentioning Cellular Molecular Biology and Neurosciences of the University of Chile, in conjunction with Felipe Bravo-Moraga, PhD student in Sciences mention Modeling Of Chemical and Biological Systems of the University of Talca. In addition, They participated in the publication Evelin González, Leslie Hernández-Cabello, Jans Alzate-Morales, Victoria Guixé Leguía and Víctor Castro-Fernández.
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article:
Cover:
Description:
Enzyme promiscuity is considered a key property for the evolution of new functions in enzymes, where the reconstruction of ancestral sequences is a powerful tool to investigate the emergence of new functions in natural enzyme lineages. This cover image depicts some techniques used to characterize an ancestral enzyme: an X-ray crystallography pattern and a phylogenetic tree from which the structure of the ancestral enzyme studied emerges. The substrates studied in the article are shown as spheres and bars; pyridoxal (vitamin B6) in yellow and hydroxymethylpyridine (intermediary of vitamin B1 synthesis) in orange.
Proteins Society:
The Proteins Society is a non-profit academic society. Since 1985, Proteins Society has been the intellectual home of researchers around the world, involved in the study of protein structure, function and design. Proteins Society provides forums for scientific collaboration and communication and supports the professional growth of young researchers through workshops, networking opportunities and encouraging young researchers to participate fully in the Proteins Society's annual Symposium. In addition to the meeting, the Society's prestigious Protein Science Journal, edited by Brian Matthews, serves as an ideal platform to promote protein science in the broadest possible sense.
Journal Protein Science:
The prestigious journal Protein Science serves as an international forum for publishing original reports on all scientific aspects of proteins. The journal publishes articles by leading scientists around the world reporting on advances in understanding proteins in the broadest sense.