May 25: Seminar ACCDiS "infection by Helicobacter pylori and gastric cancer: role of gamma-glutamyl transpeptidase virulence factor"

The Center for advanced chronic diseases is pleased to invite you to participate in its cycle of seminars per year 2017

"Infection by Helicobacter pylori and gastric cancer: role of gamma-glutamyl transpeptidase virulence factor"

Dr. Jimena Bravo
Postdoctorada ACCDiS
PhD in Physiology and nutrition from the University of Navarra, Pamplona, Spain. Study of potential antioxidant capacity and genoprotectora of coffee by-products.FONDECYT Postdoctoral Fellowship

Thursday 25 of may 2017
09:00 hrs.
Auditorium cognac
Floor - 1
Seminar 86
Providence
Santiago.

OVERVIEW

Helicobacter pylori (H. pylori) is the main risk factor associated with the development of gastric cancer. This bacteria gram-negative colonizing the gastric epithelium of about 50% of the world population, with this percentage 75% in Chile. They are multiple virulence factors involved in the pathogenicity of H. pylori, including cagA and VacA, however in recent years the soluble factor gamma-glutamyl transpeptidase has acquired great interest. Autophagy is a catabolic process conserved in eukaryotes involved in the maintenance of cell homeostasis, but has also been that it fires as a mechanism of defence in response to infection by pathogens. The precise mechanisms by which H. pylori manipulates Autophagy in infected cells are not known at all, also none of the studies available in the literature considers the role of gamma-glutamyl-traspeptidasa, so the effect of this factor of virulence in Autophagy could be relevant to understand how contributes or predisposes to the development of the pathology.