Incorporation of the teacher Rosalba Lagos

Incorporation of the teacher Rosalba Lagos

The Chilean Academy of Sciences joined the Dr. Rosalba Lagos Mónaco as a corresponding member

The President of the Chilean Academy of Sciences, Dr. Juan a.. Asenjo communicated in public session the incorporation of the teacher Rosalba Lakes Monaco as a member of this prestigious institution. The speech was in charge of the academic Dr. María Cecilia Hidalgo.

PhD in Sciences with a major in biology and Professor Titular of the Faculty of Sciences of the University of Chile, the researcher Rosalba Lakes Monaco, was appointed corresponding member of the Chilean Academy of Sciences on October 21 of this year. Professor Juan. A. Asenjo, national prize of Sciences applied and technological (2004), said that the Lagos DRA. broadly meets the requirements which stipulates the regulations of the Corporation to be elected, i.e., to be a reliable, active, renowned scientist and older than 35.

Dr. María Cecilia Hidalgo, number member of the Chilean Academy of science and national prize of natural sciences (2006), carried out the CV of the new Member. It stood out among his academic achievements, the Foundation in 1987 doctorate in microbiology taught jointly between the University of Chile and the University of Santiago de Chile as well as the creation of the Ph.d. in Molecular biotechnology of the University of Chile. Among other aspects highlighted its participation in scientific societies both nationally, as President of the society of biology in the period 2013-2014, and at the international level as Vice President of the division of bacteriology and microbiology applied of the International Union of Microbiological Societies (IUMS) for the period 2014-2017.

Incorporating speech entitled""Ancestral struggle between bacteria: their weapons, a therapeutic solution for the 21st century"the Professor Lagos explained his research around a protein produced by bacteria, with antibacterial effect on other bacteria. The production of protein compounds known as bacteriocins may have ecological significance, since it would promote the balance of bacterial diversity. This concept today is especially taken into account in the development of new bacterial antibiotics, which are specific to a particular pathogenic microorganisms, not eliminate the non-pathogenic bacteria. There is a current research posed by killing all the bacteria produces an imbalance in the Microbiome, which is associated with diseases such as diabetes, obesity, asthma, allergy, and intestinal inflammation.

The Lagos Krueger has devoted much of his research career to discover the properties of the microcina E492, a bacteriocin which form pores in the cytoplasmic membrane. From the point of view of biotechnology, one of the promising findings is called Trojan horse strategy. The microcina is inserted in bacteria through receptors that is used to pick up the iron, an element essential for bacterial growth, but what really goes into is a toxic molecule that will cause his death. One of the potential applications of identifying a part of the molecule of the microcina recognized by these receptors is that you can add, through genetic engineering, another compound so you have a toxic property. "You can make up an antibiotic for a particular pathogen known receptors and optimizing the mechanism of action", explains the researcher. Another potential use is to develop cells that them can be used as probiotic.

The Lagos Krueger has investigated another interesting aspect of protein microcina E492, which is able to produce amyloid fibers, whose structural properties are similar to those that occur in diseases such as Alzheimer's and Parkinson's. In bacteria, the production of amyloid seems to have a different function to what happens to the above complications, since these fibers could serve you for membership in certain environments. In the case of microcina E492, amyloid formation serves to inactivate the protein, as a way of regulating toxic capacity.

Finally, in addition to the antimicrobial property, microcina E492 has activity on malignant cells. "Some time ago we did a study in which we demonstrate that it induced apoptosis, which is known as programmed cell death," said the professor. This finding is key in therapies against cancer because if I had to choose the form of eliminating cancerous cells it would be through apoptosis, since it is natural death and produces no inflammatory response.