They register the Curcumin-based therapy against tumor cells - Las Últimas Noticias, 05 December 2017

They register the Curcumin-based therapy against tumor cells - Las Últimas Noticias, 05 December 2017

Andrew Quest and Felipe Oyarzún scientists discovered that they can kill tumor cells of human In Vitro.

Myth: the products made on the basis of Curcumin (turmeric from molecule) have properties that prevent diseases, including cancer.

Reality: Curcumin is a complex molecule, which starting does not dissolve in water and is extremely fragile. So much so, says Felipe Oyarzún, academic Department of science and technology pharmaceutical of the U. of Chile, which may die with excess light and even with oxygen.

"One swallows it and very little enters the body. Let's say that it gives some protection to the intestine, but if consumed in that way not serves as a treatment and less for cancer", adds Andrew Quest, who is an academic at the school of Medicine of the same House of studies.

18 years Quest came from Switzerland to establish a new line of research. I wanted to answer why it develops cancer to create a therapy, at least for animal models. And he succeeded. That Yes at age 16 have been established in Santiago.

Quest and Oyarzun, both researchers at the Centre for advanced chronic diseases, created a nanoemulsion based Curcumin, a formulation that contains very small particles and it seems vanilla milk. "This way they can reach all the alleys of the body and there is more contact with the tissues. What makes the Curcumin is interact with cells and kill them,"explains Oyarzun.

And how is it applied? "The animal model (melanoma) tumor grows, and we then extirpamos it. Then apply the nanoemulsion in the tissue just before closing the wound", details Quest. He added that the result was that recurrence of tumor or metastases there was no.

Scientists had such good results that ventured to try the same nanoemulsion in tumor cells of human, this time derived from cancers of the breast, colon and gallbladder. It was technique In Vitro.

How did it? "We measure the viability and cell death. Malignant cells died and the normal survived", celebrates Quest.

The inscription

"What we are going to do year-end is register the patent for the specific way in which it applies the nanoemulsion; the composition is already patented"said Oyarzun.

Juan Pablo García Huidobro, PhD in pharmacology from the University of California San Francisco and researcher at the Center for the development of nanoscience and nanotechnology of the Usach, says that "nanoparticles are a new way to manage drugs and have been very successful in antitumor treatments. Allow the slow drug, and sustained release which extends the time that is in the body".

Alejandro Corvalán, academic in the Faculty of Medicine of the PUC and researcher at the Center for cancer research, adds: "Oyarzun and Quest have a pre-clinical study. "I think that the trial design is to define the clinical application, that would be associated with relapses (comebacks) premises of tumors".