World RNA Day was celebrated in August

World RNA Day was celebrated in August

Every August 1, since 2018, World RNA Day is celebrated, the molecule that contains the information transcribed from DNA for the production of proteins. The date, originally proposed by Uruguayan biochemist Juan Pablo Tosar (one of the first to postulate the existence of extracellular ribosomes), was put to a vote among RNA members. Society and obtained about 90% of the votes of those who participated. In addition to their importance in protein synthesis, RNA molecules have multiple catalytic and regulatory functions. Basic research in RNA is important both in the design of therapies for, for example, neurodegenerative diseases and in understanding the mechanisms that account for the productivity of vegetable crops.

As an example of the above, messenger RNA (mRNA) has been installed as a new category of therapeutic agent for the prevention and treatment of various diseases. To function properly Vivo mRNA requires safe and effective delivery systems that protect it from degradation, allow its entry into cells and its subsequent release into the cytoplasm. Lipid nanoparticles have been shown to be particularly useful for that purpose; in particular, mRNA vaccines conveyed in the form of lipid nanoparticles that are being used clinically against SARS-Cov2 virus disease, coronavirus 2019 (COVID-19), marking a milestone for mRNA therapeutics. The authors discuss the design of lipid nanoparticles, examine physiological barriers and possible routes of administration for mRNA systems conveyed in lipid nanoparticles. In addition, they consider what they call key points for the clinical use of mRNA formulations in lipid nanoparticles, which include good manufacturing practices, stability, storage and safety, mentioning preclinical and clinical studies of mRNA therapeutics in lipid nanoparticles for infectious diseases, cancer and genetic disorders. Finally, the authors offer a perspective of the future possibilities and remaining challenges for this promising technology.

See the article in: https://www.nature.com/articles/nrd.2017.243