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Deciphering cancer: Genomic instability in cancer – Now Complimentary on Demand

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In case you missed our live, online educational seminar, “Deciphering cancer: Genomic instability in cancer,” we wanted to let you know that it is available in our complimentary on-demand archive.

You can access this archive to watch the webinar at any time.

For more information and access to the archive, go to:

About This Webinar

While it is well established that DNA damage can increase the risk of cancer, changes to the epigenome or the chromatin architecture are equally important. DNA damage triggers a redistribution of DNA-binding proteins around the site of damage, resulting in localized and temporary alteration of chromatin structure. However, repeated cycles of DNA damage and repair may lead to permanent changes in the epigenome, thereby promoting the onset of pathological diseases such as cancer. This webinar will examine how we may be able to develop effective new therapeutic options for cancer treatment by targeting proteins responsible for chromatin modifications.

During the webinar, the speakers will:

• Highlight the mechanisms of tumorigenesis and genomic instability resulting from copy number gains
• Explain the different forms of DNA damage that lead to genomic instability and tumorigenesis
• Investigate how understanding genomic instability can inform the development of cancer treatments.


Johnathan R. Whetstine, Ph.D.
Massachusetts General Hospital and Harvard Medical School
Charlestown, MA

Mark J. O’Connor, Ph.D.
Cambridge, UK

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Produced by the Science/AAAS Custom Publishing Office and sponsored by Cell Signaling Technology.