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Deciphering neurodegeneration: Inflammation, immune response, and Alzheimer’s – Now Complimentary on Demand

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In case you missed our live, online educational seminar, “Deciphering neurodegeneration: Inflammation, immune response, and Alzheimer’s” we wanted to let you know that it is available in our complimentary on-demand archive.

You can access this archive to watch the webinar at any time.

For more information and access to the archive, go to:

About This Webinar

There is growing recognition that the nervous and immune systems interact under both healthy and diseased conditions. This offers an excellent opportunity to define the role and molecular characteristics of neuroinflammation in neurodegenerative disorders. Chronic activation of the innate immune system is now well established as an underlying factor contributing to neurodegeneration—the progressive dysfunction and loss of neurons in the central nervous system leading to cognitive and motor disorders such as Alzheimer’s, Parkinson’s, amyotrophic lateral sclerosis, and others. Microglia, the primary immune cells of the brain, are critical in the maintenance of brain homeostasis, but lose their functionality during the course of aging and neurodegenerative diseases. While the majority of innate immune responses to disease stressors are mediated by the microglia, perivascular macrophages and peripheral myeloid cell populations can also gain access to the diseased brain and participate in neuroinflammatory signaling. Thus, a better understanding of how immune responses regulate neuronal homeostasis, and of the circumstances leading to dysregulation in pathological conditions, is essential to developing effective therapies and mitigating disease impact. In this webinar, speakers will share their research on immune response–mediated onset of neurodegenerative diseases, and explain the genetic and physiological regulation of microglial function in both healthy and diseased states.

During the webinar, the viewers will:

• Hear about the potential role of innate immunity in neurodegeneration and cognitive function, particularly in Alzheimer’s disease
• Learn how immune-related pathways regulate the development, refinement, and elimination of specific axons and synapses during development
• Gain an understanding of how recent work can provide insight into protecting synapses in neurodegenerative and psychiatric disorders of synaptic dysfunction.


Beth Stevens, Ph.D.
Children’s Hospital Boston
Boston, MA

Todd E. Golde, M.D., Ph.D.
University of Florida
Gainesville, FL

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Produced by the Science/AAAS Custom Publishing Office and sponsored by Cell Signaling Technology

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