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Fermentation Scientist I/II
Berkeley, CA, US
Lygos – Full-Time | Job date : 02-28-2018
DESCRIPTION
Lygos is a synthetic biology company developing novel microbial technologies for the fermentative production of commodity and specialty chemicals. Lygos identifies expensive, environmentally hazardous, and harmful chemical and petrochemical production processes used today and develops safe, renewable routes to the same products. Lygos is seeking to hire a skilled Scientist to support its fermentation needs to develop and evaluate strains producing a variety of products.
Position Description The successful applicant will lead strain screening and process development campaigns to identify and develop strains for improved production of bio-based chemicals. The applicant is expected to implement efficient experimental approaches to identify and develop improved fermentation production processes. Research objectives are milestone-driven (e.g. strain performance versus time, and meeting throughput targets for successfully-completed fermentations).
REQUIREMENTS
Responsibilities
Work in close collaboration with molecular biology and downstream processing to efficiently and accurately test hypotheses and reach key metric goals.
Independently conceive, design, plan, and complete fermentation experiments to improve fermentation performance metrics (productivity, yield, titer).
Supervise a research assistant to support experimental design and operations.
Prepare and present results, scientific findings, technical reports, and protocols.
Transfer fermentation processes to external piloting and manufacturing sites. Adjust procedures and troubleshoot scale-up as needed.
Education and Experience
A Ph.D. or M.S degree with 2+ years of relevant industrial experience in chemical engineering or related field.
A minimum of 3 years fermentation experience in an industrial or academic setting.
Proven experience successfully working within collaborative teams including supervising interns, students, or research assistants.
Energetic, hard-working, creative, team player.
Demonstrated technical proficiency, scientific creativity, and collaboration.
Strong organization skills and proven ability to manage details.
Effective problem solver that is willing to reprioritize efforts regularly and take on diverse responsibilities within a fast-paced, dynamic start-up company environment.
Strong hands-on technical abilities including maintaining and repairing basic lab equipment.
Experience working with a range of microorganisms a plus.
Experience writing standard operating procedures and batch records, and supporting technical transfer of fermentation processes to external sites.
Experience with pilot and commercial-scale fermentation operations.
Familiarity with Sartorious and Applikon equipment a plus.
Secondary Knowledge and Skill Considerations
Experience working with a range of microorganisms a plus.
Experience writing standard operating procedures and batch records, and supporting technical transfer of fermentation processes to external sites.
Experience with pilot and commercial-scale fermentation operations.
Familiarity with Sartorious and Applikon equipment a plus.
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Assay Development Research Associate
Emeryville, CA, US
Diassess – Full-Time | Job date : 02-27-2018
Description: As Research Associate at Diassess Inc., you will be working with the Scientific team in the development of several molecular assays for Diassess. The position will be a combination of experimental design, reagent and assay setup, data analysis, product development and presentation of results. You will become a vital part of the Diassess team, aiding in the development of the company’s assay technology, and will play a large part in the development of the company.
About us: Diassess is a startup striving to transform the way infectious diseases are diagnosed. We are developing a disposable test kit that allows any cell phone to perform rapid DNA and protein-based disease detection, in a clinic or at-home, within 30 minutes. This technology bypasses centralized medical lab testing and streamlines patient care. Diassess is currently located in Emeryville, CA.
Our Vision: Healthcare costs are 18% of USA GDP, 50 million Americans are uninsured, and in some regions of the world, healthcare is nonexistent. Our company is trying to upend the current institutional practice of healthcare, in America and around the world. Ideal candidates will share our vision and passion for improving healthcare delivery across the world.
Primary Job Function:
Help in development of existing and new products
Design and conduct experiments in a laboratory setting and assist with a wide variety of analytical and clinical trials
Perform reaction setup of molecular assays in different lab environments
Interact with and maintain relationships with vendors and external contractors
Design of experiments and evaluation of results with autonomy
Maintain clear and concise documentation of developed processes in a lab notebook
Place orders and keep track of inventory needs for large projects
Prepare reports on experimental and clinical studies
Significant Work Activities and Conditions: You have worked with molecular biology assays and you know that sometimes setting up a reaction can take prolonged periods of time sitting in a chair. Don’t worry though, we like to run, dance, climb, and drink coffee when we are not sitting down.
Benefits: Diassess offers the following benefits to all its employees:
Competitive salaries and meaningful equity.
Unlimited PTO and flexible hours with an emphasis on a healthy work/life balance.
Health, vision, and dental insurance w/ FSA.
Life and long-term disability insurance.
401(k) retirement savings plan.
Parental leave.
Relocation support.
Choice of gym membership or commuter benefits.
Weekly group lunch and a fully stocked snack kitchen.
Your choice of professional equipment and software.
Relaxed and collaborative culture.
One block from Emeryville BART shuttle stop.
Many cafes, bars, and restaurants within a 5 min walk.
Diassess is an Equal Opportunity Employer. Individuals seeking employment at Diassess are considered without regards to race, color, religion, national origin, age, sex, marital status, ancestry, physical or mental disability, veteran status, gender identity, or sexual orientation.
Qualification
Education: BS or MS in Molecular Biology, Biochemistry or a closely-related field.
Experience and Training: Previous experience working in a scientific laboratory is required. Candidates should have demonstrated ability to work autonomously and independently in a laboratory setting.
Skills: The ideal candidate would possess most of the following skills and would be excited to learn the rest:
Experience with nucleic acid amplification based assays like PCR and operating lab instruments such as thermocyclers.
Demonstrate an understanding of different DNA detection modalities such as molecular beacons, intercalating dyes, etc.
Able to think on their feet and troubleshoot equipment and setups.
Understands the importance of collaboration both cross-functionally within the company and with contractors and manufacturers.
Shows strong work ethic, drive and attention to detail.
Shows admirable skill set in problem solving, time management and multitasking.
Drive to work both individually and in a team environment.
Excellent communication and interpersonal skills.
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Process Development Research Associate
Berkeley, CA, US
Caribou Biosciences – Full-Time | Job date : 02-21-2018
Description
Caribou Biosciences, Inc. is a leading company in CRISPR genome engineering located in Berkeley, CA. Caribou’s tools and technologies provide transformative capabilities to therapeutic development, agricultural biotechnology, industrial biotechnology, basic and applied biological research. The five-year-old company has developed a best-in-class CRISPR genome engineering technology platform and has a leading intellectual property position
We are seeking a Process Development Research Associate or Scientist to join our newly created Process Development group in Berkeley. The ideal candidate will interact closely with functional group leaders, scientists and research associates to transfer the technology from discovery to pre-clinical development.
Responsibilities will include:
Develop cell separation, cell enrichment, gene editing, formulation and related processes for scale-up
Use engineering principles to leverage bench and pilot scale models for process performance characterization
Participate in the identification and selection of CMO/CRO partners
Transfer technologies to CMO/CROs and provide training and on-going technical support
Design and execute characterization studies, evaluate product impact of scale-up and/or raw material changes, and apply scientific and engineering principles to investigate non-conformance and develop corrective and preventive actions
Optimize scale-up of operations with quality assurance methodologies
Generate development reports and prepare SOPs and batch records
Oversee development of analytical methods for product evaluation and release
Participate in preparation of CMC sections of regulatory filings including supporting documents, reports and change controls
Participate in cross-functional teams, working in a highly matrixed team environment to advance preclinical programs
Candidate must possess:
Bachelor’s degree, Master’s degree or equivalent experience in Biochemistry, Bioengineering, Molecular Biology or a related field
Minimum of 3 years of experience in process development working in research or manufacturing operations in pharma or biotech
Extensive experience managing cell-based process development and technology transfer
Ability to manage CMO/CRO interactions and maintain professional and productive relationships
Experience with statistical design of experiments, advanced data analysis and Quality by Design concepts
Excellent verbal and written communication skills
Proven ability to work independently, as well as to collaborate with peers and work effectively in a fast-paced team-oriented environment
Strong organizational, time management, communication and interpersonal skills
Pluses:
Experience interacting with CMO/CRO partnerships
Background in immunology or immune cell engineering
Experience developing and transferring gene engineering based cell therapies toward GMP
Caribou Biosciences, Inc. is a dynamic start-up company, and the successful candidate must have the ability and desire to work in a fast-paced environment. For more information, please visit www.cariboubio.com. Caribou is on Twitter. Sign up to follow our Twitter feed @CaribouBio.
Caribou offers a comprehensive compensation package, as well as generous paid time off in addition to Company-observed holidays. The Company provides medical, dental, and vision insurance, along with a 401(k) retirement savings plan which includes matching employer contributions. Caribou promotes a culture in which employees are respected and rewarded for hard work, innovation, personal initiative, and teamwork.
Caribou is an equal opportunity employer and does not unlawfully discriminate on the basis of race, color, religion, citizenship, political activity or affiliation, marital status, age, national origin, ancestry, physical or mental disability, medical condition (as defined under California law), veteran status, sexual orientation, gender identity, gender expression, sex or gender (which includes pregnancy, childbirth, breastfeeding, or related medical conditions), taking or requesting statutorily protected leave, or any other basis protected by law. In addition, Caribou prohibits the harassment of any individual on any of the bases listed above or any other characteristics protected under federal, state, or local laws.
Direct applicants only. No agencies please.
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Scientist, Protein Sciences
San Francisco, CA, US
Nurix – Full-Time | Job date : 02-22-2018
Description
Join us in the most challenging and rewarding science of our lives.
We are seeking a highly skilled and motivated scientist with expertise in Protein Sciences to join Nurix’s Discovery team.
You will provide scientific leadership in Nurix’s protein expression and purification efforts to support biochemical, biophysical and structural efforts. You will play a key role in the implementation of higher throughput methodologies to expand protein sciences capabilities. You will work closely with an experienced team of interdisciplinary scientists and have regular opportunities present findings to the project team and senior management.
You should have a strong desire to learn new techniques and incorporate new methodologies into your work. You must be self-driven, resourceful, organized and focused, and enjoy being a part of a dynamic team in a project-based environment solving challenging scientific problems to benefit patients.
Qualifications
Ph.D. in Biochemistry, Cell and Molecular Biology, or related field with 3+ years post-degree industry experience
Expertise in construct design, protein expression & purification, and protein characterization pertinent to small molecule drug discovery
Experience with protein production including multiprotein complexes in bacterial, baculovirus and mammalian expression systems
Knowledge of expression platforms, purification systems and analytical techniques (e.g. Wave bioreactor, AKTA, HPLC/MS, TFF)
Familiarity with the development of higher throughput methodologies and automated technologies for protein purification
A strong track record (publications, industry experience) with excellent interpersonal skills
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Cancer Immunologist
Foster City, CA, US
Notable Labs – Full-Time | Job date : 02-20-2018
Description
We’re currently looking for a curious, inspired cancer immunologist to join our research and development team. We work in an incredibly fast-paced environment that thrives on innovation and creativity. Given our small size, you’ll make valuable contributions to the goals and strategic direction of both the science team and the company broadly. Just as you are investing in us, we want to invest in you. As the founding member of our cancer immunology program, you’ll have generous opportunities for personal and professional growth. As a member of a transformative translational medicine platform, you’ll personally have a direct impact on patient outcomes today, as well as the future of cancer care.
Ready for action? If you’re ready to build something amazing….you belong with us.
What we can offer you:
Resources to support lightning speed research – Notable’s lab is fully automated with hardware and software tools that allow scientists to perform hundreds of R&D experiments without touching a pipette. Use your time designing innovative experiments and analyzing data – and give your thumb a rest.
The chance to directly fight cancer, one patient at a time. You will not just be doing long-term research. You will be impacting lives TODAY.
Exposure to experts from diverse backgrounds ranging from engineering, data science, operations, clinical medicine, patient advocacy, and beyond
A collaborative environment and a team dedicated to both personal and scientific growth and development
Highly competitive, early stage company compensation package, with incredible growth opportunities
Outstanding healthcare benefits
Flexible vacation policy
… did we mention daily catered lunch?
What you will bring to the role:
PhD in cell biology, immunology, cancer immunology or other related field – or equivalent industry experience
Strong technical background in cancer immunology and flow cytometry
Exceptional experimental design skills:
Can you efficiently plan the best experiments possible to get to your goal?
Can you use creativity and scientific intuition to design better experiments?
Expert data analysis skills:
Can you catch what no one else sees in the data?
Are you capable of quickly re-orienting when faced with something unexpected?
Can you troubleshoot even the most confusing findings in the data?
Organization and Communication:
Can you efficiently pull the most relevant information out of raw data and bring your colleagues up to speed?
Can you communicate progress and road blocks effectively?
Additional Qualifications:
Compassion for cancer patients and passion for reinventing cancer treatment
Hustle and relentless resourcefulness
Strong project management skills – ability to lead and organize group efforts
Attitude of continuous improvement: Can you create processes that can then run without you? Do you enjoy building pipelines to improve efficiency in your own experiments / data analysis?
Excellent time management and creative problem solving skills
Self-starting, flexible, positive mindset – quick adaptation to new situations
Strong written and oral communication skills and enthusiasm
Collaborative, team-player attitude
Extra credit
Experience in hematological malignancies
Experience with high throughput drug screening
Previous collaboration with engineers or bioinformatics / data scientists
Experience scripting or coding
Management experience
What we can offer you:
The opportunity to directly fight cancer, one patient at a time
Exposure to experts from diverse backgrounds ranging from engineering, data science, operations, clinical medicine, patient advocacy, and beyond
Work in a collaborative environment with a team dedicated to both personal and scientific growth and development
Highly competitive, early stage company compensation package, with incredible growth opportunities
Outstanding healthcare benefits
Flexible vacation policy
… did we mention daily catered lunch?
More about us:
Notable Labs is a precision medicine company that has a translational drug discovery platform focused on identifying therapeutic options for relapsed and refractory cancer patients.
Our clinical research lab helps oncologists identify personalized combinations of existing FDA-approved treatments for patients. We’ve developed a high throughput robotic flow cytometry lab platform that screens thousands of FDA-approved drug combinations against the patient’s own cancer cells to help predict safer and more effective cancer treatments. Our lab has completed initial feasibility studies with clinicians in relapsed Acute Myeloid Leukemia & Myelodysplastic Syndrome, with an 84% predictive rate. Focusing on individual patients and existing treatments, we’re working to discover novel uses of drugs and defining mechanisms underlying cancer progression and drug resistance.
Our research and development platform extends our clinical research to drug discovery, testing novel compounds with primary patient samples for pharmaceutical and biotechnology companies. Using our automated, high-throughput, multi-parametric drug screening research platform, industry partners can assay the biological impact of novel compounds on primary cells in a physiologically relevant environment. This helps our partners stratify patients by their predicted responsiveness, increasing the probability of successful clinical development. We are actively partnering with pharmaceutical companies that have preclinical and clinical stage drug pipelines in Acute Myeloid Leukemia, Myelodysplastic Syndrome, or related hematological malignancies to profile experimental drug activity in patient samples.
Our investors include Builders Venture Capital, Founders Fund, First Round Capital, Y Combinator, several prominent angels and seed-stage funds, and Accelerate Brain Cancer Cure, a venture philanthropy firm founded by Steve Case. We have offices and a laboratory in San Francisco’s SoMa district.
At Notable Labs we value diversity and are an equal opportunity employer. We do not discriminate on the basis of race, religion, color, national origin, gender, sexual orientation, age, marital status, veteran status, or disability status.
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