Skip to content Skip to sidebar Skip to footer



Deciphering cancer: Understanding tumor invasion and the metastatic microenvironment – Now Complimentary on Demand

unnamed (1)

In case you missed our live, online educational seminar, “Deciphering cancer: Understanding tumor invasion and the metastatic microenvironment” we wanted to let you know that it is available in our complimentary on-demand archive.

You can access this archive to watch the webinar at any time.

For more information and access to the archive, go to:

About This Webinar

Tumor metastasis is a multistep process that includes stimulation of angiogenesis, intravasation of tumor cells into blood or lymphatic vessels, and subsequent engraftment and extravasation to peripheral tissues where secondary tumors are seeded. It is known that metastatic progression is driven by mutational and epigenetic changes in tumor cells, but more recent efforts have focused on the evolving interplay between the tumor cell and the tumor microenvironment (TME) during invasion and transition from micrometastasis to macrometastasis. Whether the tumor cell or the subverted vascular niche/premetastatic niche is the driver of TME evolution remains the subject of debate. This webinar examines the role of tumor-secreted factors, including exosomes and tumor vascular niche–derived protumorigenic factors in tumor–environment interactions, and their implications for development of therapeutic interventions to arrest metastasis.

During the webinar, the viewers will:

• Hear about the importance of the TME for tumor progression and metastasis
• Be introduced to the concept of the vascular niche/premetastatic niche and its role in metastasis
• Learn how angiocrine-derived factors dictate tumor stemness.


David C. Lyden, M.D., Ph.D.
Memorial Sloan Kettering Cancer Center
New York, NY

Shahin Rafii, M.D.
Weill Cornell Medical College
New York, NY

Register at:

Questions? E-mail:

Produced by the Science/AAAS Custom Publishing Office and sponsored by Cell Signaling Technology.