The Biophysical Journal is pleased to congratulate Dr. Arthur Ashkin for sharing in the 2018 Nobel Prize in Physics for his development of optical tweezers. Members of the Biophysical Society have long recognized and appreciated the power of this technology, and early work by our members (e.g., Howard Berg, Steven Block, James Spudich, Carlos Bustamante, and many others) played foundational role in its development as a high-resolution tool to address fundamental biological questions. The Biophysical Journal regularly publishes papers using optical tweezers to discover the mechanisms of molecular motors and other mechanoenzymes, resolve the forces and kinetics of molecular bonds, reveal the energy landscapes of protein and nucleic acid folding, manipulate and microfabricate biological structures, and determine the material properties of biological networks. Here, we highlight 12 recent Biophysical Journal papers that use optical tweezers.
- Dissecting the Dynamic Pathways of Stereoselective DNA Threading Intercalation
- Switching between Exonucleolysis and Replication by T7 DNA Polymerase Ensures High Fidelity
- Mechanical Folding and Unfolding of Protein Barnase at the Single-Molecule Level
- Single-Molecule Chemo-Mechanical Spectroscopy Provides Structural Identity of Folding Intermediates
- Intact Telopeptides Enhance Interactions between Collagens
- Structure-Based Derivation of Protein Folding Intermediates and Energies from Optical Tweezers
- Quantifying Instrumental Artifacts in Folding Kinetics Measured by Single-Molecule Force Spectroscopy
- Detailed Analyses of Stall Force Generation in Mycoplasma mobile Gliding
- Probing Mitotic CENP-E Kinesin with the Tethered Cargo Motion Assay and Laser Tweezers
- Fibrin Networks Support Recurring Mechanical Loads by Adapting their Structure across Multiple Scales
- Adaptive Response of Actin Bundles under Mechanical Stress
- β1-Integrin-Mediated Adhesion Is Lipid-Bilayer Dependent
View the Collection
E. Michael Ostap
Editorial Board Member
Biophysical JournalSection: Molecular Machines, Motors, and Nanoscale Biophysics
Section: Nucleic Acids and Genome Biophysics
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