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Webinar: Sensitive and Robust Analysis of Emerging Contaminants in Water

In this webinar we will present how to optimize the routine LC/MS/MS analysis of emerging contaminants in water like PFAS and algal toxins, in order to generate sensitive, robust and accurate data.
The chemical properties of per/polyfluoroalkyl substances (PFAS) or perfluorinated compounds (PFCs) make them attractive to use in a variety of areas, such as non-stick cookware, fire resistant clothing, and fire-fighting foams. Due to their persistence, toxicity and bioaccumulation in the environment, they are of great concern. USEPA Method 537 highlights a method for the analysis of 14 PFASs in drinking water with solid phase extraction (SPE) and LC/MS/MS. However, several other classes of PFASs are also currently in use and need to be monitored in the environment. Here we will discuss the analysis of 30 PFASs in eight different classes, including all 14 PFASs in EPA Method 537, using a single analytical method on an triple quadrupole LC/MS system. Alternate methods for analysis of non-potable water will also be presented.
Microcystins (MCs) are cyclic peptides containing seven amino acids. Their occurrence in fresh waters is a serious environmental and public health concern, because MCs are powerful hepatotoxins. Two EPA methods describe the analyses of algal toxins in drinking water using LC/MS/MS. EPA Method 544 (2015) includes 6 MCs plus Nodularin-R, and EPA Method 545 analyzes cylindrospermopsin and anatoxin-a. Results using a triple quadrupole LC/MS system and a LC/QTOF system will be presented.
  • Optimization of the analysis of per and polyfluoroalkyl substances in water included in USEPA and ASTM methods
  • Quantification of algal toxins including microcystins included in USEPA methods 544 & 545
  • Identification of unknown algal toxins using quadrupole time-of-flight mass spectrometry

Ralph Hindle, Senior Chemist,Vogon Labs
Ralph Hindle is an experienced Senior Chemist with a diversified portfolio in trace organic analytical chemistry. Ralph received his B.Sc. in 1976 from the University of Ottawa (Ottawa, ON). Since then he has acquired 20 years of lab experience in the federal government, and has been working in private industry since 1996. He is the founding president of three incorporated laboratories, including Vogon Labs. Ralph has performed and developed analytical methods for a wide range of target chemicals including pesticide residues in foods, human and veterinary drugs, pharmaceuticals and personal care products and other environmental contaminants in water, soil, food and feed and biological matrices. He has extensive expertise in applications of GC-MS, LC-MS, GC-MS/MS and LC-MS/MS.


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